As Jesus concluded His denunciation of the scribes and Pharisees, He revealed the severe penalty coming upon them for perverting the religion of God,
“Therefore, indeed, I send you prophets, wise men, and scribes: some of them you will kill and crucify, and some of them you will scourge in your synagogues and persecute from city to city, that on you may come all the righteous blood shed on the earth, from the blood of righteous Abel to the blood of Zechariah, son of Berechiah, whom you murdered between the temple and the altar. Assuredly, I say to you, all these things will come upon this generation” (Matthew 23:34–36).
Their long history of persecuting the prophets of God, would culminate with that generation when the Lord would punish them for their error in the destruction of Jerusalem, AD 70.
God does not take lightly the persecution of the messengers whom He sends to warn people of how they have violated His will.