David knew how it felt to have people turn against him. Evidently he had become sick, even to the point of death, and his enemies looked forward to him dying (Psalm 41:5-8). Then David experienced the ultimate hurt,
Even my own familiar friend in whom I trusted, Who ate my bread, Has lifted up his heel against me. (Psalms 41:9)
Few things hurt more than that. You have a close friend in whom you have trusted, then he turns against you. How do you describe the confusion in your heart?
Jesus also knew how that felt, because in the fullness of time, that passage spoke of what Judas did to Jesus. Even Jesus questioned what Judas did, not that Jesus was surprised, but He felt the pain.